Biography

Dr. Mabuchi, Senior Scientist, received an M.D. from Osaka University Medical School, and an M.P.H. / Dr.PH. from the John Hopkins University School of Hygiene and Public Health. He joined the DCEG Radiation Epidemiology Branch in 2000 after serving as Chief of the Department of Epidemiology at the Radiation Effects Research Foundation, Hiroshima, Japan, where he led the long-term epidemiological studies of health effects of radiation exposure in cohorts of atomic bomb survivors and their children. He has been a member of several international radiation committees, including the International Commission of Radiological Protection (ICRP), the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), UK National Radiological Protection Board’s Advisory Group on Ionizing Radiation and also formerly a member of the Executive Committee of the International Association of Cancer Registries.

Research Interests

• Cancer risks associated with exposure to ionizing radiation and how the radiation-related risks are modified by modes of exposure and other factors including age, gender, time as well as other host and carcinogenic factors
• The risk and dose-response for chronic diseases other than cancer associated with exposure to ionizing radiation
• The risks of non-melanoma skin cancers associated with non-ionizing ultraviolet (UV) radiation and how the risks are modified by types of UV exposure and other factors including ionizing radiation exposure and host factors

Selected Publications

• Preston DL, Cullings H, Suyama A, Funamoto S, Nishi N, Soda M, Mabuchi K, Kodama K, Kasagi F, Shore RE. Solid cancer incidence in atomic bomb survivors exposed in utero or as young children. J Natl Cancer Inst 2008 Mar 19;100(6):428-36.
• Ha M, Mabuchi K, Sigurdson AJ, Freedman DM, Linet MS, Doody MM, Hauptmann M. Smoking cigarettes before first childbirth and risk of breast cancer. Am J Epidemiol 2007 Jul 1;166(1):55-61.
• Karagas MR, Nelson HH, Zens MS, Linet M, Stukel TA, Spencer S, Applebaum KM, Mott L, Mabuchi K. Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure. Epidemiology 2007 Nov;18(6):776-84.
• Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, Mabuchi K, Kodama K. Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res 2007 Jul;168(1):1-64.
• Mizuno T, Tokuoka S, Kishikawa M, Nakashima E, Mabuchi K, Iwamoto KS. Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations. Carcinogenesis 2006 Nov;27(11):2286-94.
• Hirai Y, Kodama Y, Moriwaki S, Noda A, Cullings HM, Macphee DG, Kodama K, Mabuchi K, Kraemer KH, Land CE, Nakamura N. Heterozygous individuals bearing a founder mutation in the XPA DNA repair gene comprise nearly 1% of the Japanese population. Mutat Res 2006 Oct 10;601(1-2):171-8.
• Kishikawa M, Koyama K, Iseki M, Kobuke T, Yonehara S, Soda M, Ron E, Tokunaga M, Preston DL, Mabuchi K, Tokuoka S. Histologic characteristics of skin cancer in Hiroshima and Nagasaki: background incidence and radiation effects. Int J Cancer 2005 Nov 10;117(3):363-9.
• Carr ZA, Land CE, Kleinerman RA, Weinstock RW, Stovall M, Griem ML, Mabuchi K. Coronary heart disease after radiotherapy for peptic ulcer disease. Int J Radiat Oncol Biol Phys 2005 Mar 1;61(3):842-50.
• Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH, Linet MS, Ron E, Mabuchi K. Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists. Int J Cancer 2005 Jul 10;115(5):828-34.
• Yoshinaga S, Mabuchi K, Sigurdson AJ, Doody MM, Ron E. Cancer risks among radiologists and radiologic technologists: review of epidemiologic studies. Radiology 2004 Nov;233(2):313-21. Review.
• Yonehara S, Brenner AV, Kishikawa M, Inskip PD, Preston DL, Ron E, Mabuchi K, Tokuoka S. Clinical and epidemiologic characteristics of first primary tumors of the central nervous system and related organs among atomic bomb survivors in Hiroshima and Nagasaki, 1958-1995. Cancer 2004 Oct 1;101(7):1644-54.
• Freedman DM, Sigurdson A, Doody MM, Mabuchi K, Linet MS. Risk of basal cell carcinoma in relation to alcohol intake and smoking. Cancer Epidemiol Biomarkers Prev 2003 Dec;12(12):1540-3.
• Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 2003 Oct;160(4):381-407.
• Preston DL, Pierce DA, Shimizu Y, Ron E, Mabuchi K. Dose response and temporal patterns of radiation-associated solid cancer risks. Health Phys 2003 Jul;85(1):43-6. Review.
• Pierce DA, Sharp GB, Mabuchi K. Joint effects of radiation and smoking on lung cancer risk among atomic bomb survivors. Radiat Res 2003 Apr;159(4):511-20.
• Hauptmann M, Mohan AK, Doody MM, Linet MS, Mabuchi K. Mortality from diseases of the circulatory system in radiologic technologists in the United States. Am J Epidemiol 2003 Feb 1;157(3):239-48.
• Sharp GB, Mizuno T, Cologne JB, Fukuhara T, Fujiwara S, Tokuoka S, Mabuchi K. Hepatocellular carcinoma among atomic bomb survivors: significant interaction of radiation with hepatitis C virus infections. Int J Cancer 2003 Feb 10;103(4):531-7.
• Preston DL, Ron E, Yonehara S, Kobuke T, Fujii H, Kishikawa M, Tokunaga M, Tokuoka S, Mabuchi K. Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure. J Natl Cancer Inst 2002 Oct 16;94(20):1555-63.
• Cologne JB, Tokuoka S, Beebe GW, Fukuhara T, Mabuchi K. Effects of radiation on incidence of primary liver cancer among atomic bomb survivors. Radiat Res 1999 Oct;152(4):364-73.
• Shimizu Y, Pierce DA, Preston DL, Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950-1990. Radiat Res 1999 Oct;152(4):374-89.
• Ron E, Preston DL, Kishikawa M, Kobuke T, Iseki M, Tokuoka S, Tokunaga M, Mabuchi K. Skin tumor risk among atomic-bomb survivors in Japan. Cancer Causes Control 1998 Aug;9(4):393-401.
• Delongchamp RR, Mabuchi K, Yoshimoto Y, Preston DL. Cancer mortality among atomic bomb survivors exposed in utero or as young children, October 1950-May 1992. Radiat Res 1997 Mar;147(3):385-95.
• Mabuchi K, Ron E, Preston DL: "Cancer Incidence Among Japanese Atomic-Bomb Survivors. In: Implications of New Data on Radiation Cancer Risk (Proceedings of the Thirty-Second Annual Meeting of the National Council on Radiation Protection and Measurements) Ed by Boice JD Jr., National Council on Radiation Protection and Measurements, pp. 41-49, 1997.
• Pierce DA, Shimizu Y, Preston DL, Vaeth M, Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990. Radiat Res 1996 Jul;146(1):1-27.
• Mabuchi K, Soda M, Ron E, Tokunaga M, Ochikubo S, Sugimoto S, Ikeda T, Terasaki M, Preston DL, Thompson DE. Cancer incidence in atomic bomb survivors. Part I: Use of the tumor registries in Hiroshima and Nagasaki for incidence studies. Radiat Res 1994 Feb;137(2 Suppl):S1-16.
• Thompson DE, Mabuchi K, Ron E, Soda M, Tokunaga M, Ochikubo S, Sugimoto S, Ikeda T, Terasaki M, Izumi S, et al. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. Radiat Res 1994 Feb;137(2 Suppl):S17-67. Review. Erratum in: Radiat Res 1994 Jul;139(1):129.
• Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramoto A, Kamada N, Dohy H, Matsuo T, Matsui T [corrected to Matsuo T, et al. Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 1994 Feb;137(2 Suppl):S68-97. Erratum in: Radiat Res 1994 Jul;139(1):129.

Collaborators

DCEG Collaborators

• Elaine Ron, PhD; Martha Linet, MD, MPH; Charles Land, PhD; Peter Inskip, PhD; Alice Sigurdson, PhD; Michele Doody, MS; Michal Freedman, PhD; Ruth Kleinerman, MPH; Kenneth Kraemer, MD; Rose Yang PhD.

Other Scientific Collaborators

• Dale Preston, PhD, Hirosoft International, CA
• Margaret Karagas, PhD, Dartmouth University
• Roy Shore, PhD, Radiation Effects Research Foundation, Japan
• Shoji Tokuoka, MD, Radiation Effects Research Foundation, Japan
• Kazunori Kodama, MD, Radiation Effects Research Foundation, Japan
• Kyoji Furukawa, PhD, Radiation Effects Research Foundation, Japan
• Ritsu Sakata, PhD, Radiation Effects Research Foundation, Japan
• Nori Nakamura, PhD, Radiation Effects Research Foundation
• Shinji Yoshinaga, PhD, National Institute of Radiological Sciences, Japan
• Stefan Lonn, PhD, Karolinska Institute, Sweden